NC Division of Public Health Statement on GenX
RALEIGH — The NC Department of Health and Human Services (NC DHHS) released a health effects statement on GenX to county public health directors on Monday, June 12, 2017. The statement was prepared for the NC Division of Environmental Quality (NCDEQ) by the Occupational and Environmental Epidemiology Branch of NC DHHS.
FULL STATEMENT:
Prepared by the Occupational and Environmental Epidemiology Branch, NC DHHS June 12, 2017
GenX is a chemical used in the manufacturing of fluoropolymer resins, which are used for nonstick coatings and other purposes. GenX is part of the perfluorinated family of compounds that includes the chemicals PFOS and PFOA. In 2009, GenX was developed as a replacement for PFOA thus limited health information is available for GenX.
According to media reports, the GenX in the Cape Fear River is originating from Chemours Co. at Fayetteville Works, a facility 100 miles upstream from Wilmington. GenX has been detected in water treated by the Cape Fear Public Utility Authority as detailed in the article by Sun et al.
The recent media reports on GenX in the Cape Fear River are associated with the paper written by Sun et al. This paper was published in November 2016. Media reports cite 631 ng/L concentrations of GenX detected in the Cape Fear River. This number is taken from the Sun et al. article based on data from 2013-2014. It is not known whether these levels reflect the current concentrations of GenX in the Cape Fear River.
Limited health information is available for GenX. PFOA and PFOS (chemicals that are part of the same family of fluorinated compounds) were recently reviewed by the EPA and the most common effects observed in laboratory tests were kidney and testicular cancer, impaired fetal development, and effects on the liver, thyroid, and immune system. The EPA recently released a Health Advisory with recommendations for drinking water not to exceed 70 parts per trillion (70 ng/L) for PFOS and PFOA combined.
There are no U.S. regulatory guideline levels for GenX. However, as part of the European chemical registration, a 2-year chronic toxicity and cancer study with rats was performed. They reported a Derived No Effect Level (DNEL) of 0.01 mg/kg bw/day. Based on U.S. risk assessment calculations, this corresponds to a concentration in drinking water of 70,909 ng/L of GenX- more than 100 times greater than the mean value of 631 ng/L detected in the Cape Fear River. Based upon these data, the GenX levels detected in 2013-2014 would be expected to pose a low risk to human health.
This summary covers GenX only and does not address other poly- or perfluorinated compounds that might be present. This summary is preliminary and subject to change as additional information becomes available.
1. Sun et al. Legacy and Emerging Perfluoroalkyl Substances Are Important Drinking Water Contaminants in the Cape Fear River Watershed of North Carolina. Environmental Science & Technology Letters. Nov 2016. DOI: 10.1021/acs.estlett.6b00398.
2. USEPA. Drinking Water Health Advisories for PFOA and PFOS. https://www.epa.gov/ground-water-and-drinkingwater/drinking-water-health-advisories-pfoa-and-pfos